![]() Naturally adding character, flavor and refreshment, the lime ritual is an integral part of delivering an experience that is truly unique to Corona. The artwork found on the bottle is painted, highlighting our commitment to quality in our packaging and our Mexican heritage. Corona is a pioneer in the beer industry by being the first to use a transparent bottle showcasing its purity and high quality to the world. Corona Extra was first brewed in 1925 at the Cervecería Modelo in Mexico City. “With the European launch of Corona Cero we now have even more options to encourage a culture of responsibility among our customers and a worthy addition to our growing range of no-and-low alcohol beers.”īorn in Mexico, Corona is the leading beer brand in the country, the most popular Mexican beer worldwide exported to more than 180 countries. ![]() Our Global Smart Drinking Goals guide us all year round in making the right choices and empowering our consumers to drink smart. Irini continued: “Smart drinking is such an important part of our company culture and, as the world’s leading brewer, we want every experience with beer to be a positive one. Over the past five years, AB InBev’s non-alcoholic portfolio has expanded significantly from 26 to 42 brands, with the launch of Corona Cero representing another important milestone in the brewer’s smart drinking ambitions. With IWSR forecasting the global no/low alcohol category total volume to grow by 31% by 2024, it’s an increasingly key part of the brewer’s portfolio.ĪB InBev’s smart drinking initiatives are underpinned by its Global Smart Drinking Goals, focused on shifting social norms, consumer behaviours, and its own business practices to make a tangible contribution to reducing harmful use of alcohol globally. Globally, AB InBev’s non-alcoholic beer portfolio delivered double-digit revenue growth in 2021, driven by several brand extensions and local launches. It’s all about giving people as much choice as possible, exploring our natural ethos even further and staying responsive to what is a rapidly growing category.” Irini Komodikis, Corona Marketing Director, Europe said “Corona has always been an invitation to enjoy more of life’s great moments outside, with close friends and a beer in hand – of course, there’s lots of occasions where we don’t want to consume alcohol while we do this. Corona Cero is available now in Belgium, Finland, France, Denmark, Germany, Netherlands, Norway, Poland, Sweden and the UK. A beer that was born at the beach, just like Corona Extra it is best served cold with a wedge of lime.ĪB InBev, the world’s largest brewing company, has announced the European launch of Corona Cero, a new non-alcoholic beer brewed with 100% natural ingredients. Still offering the classic refreshing taste of Corona, the new Cero caters for consumers looking for a non-alcoholic option with quality, 100% natural ingredients. In a major step for the brewer’s Smart Drinking Goals, Corona’s new non-alcoholic beer, brewed with 100% natural ingredients, has launched in ten European markets ![]()
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Healing can require up to eight weeks and scarring may occur. Blisters are frequently present and they are often very painful. When the injury extends into some of the underlying skin layer, it is a partial-thickness or second-degree burn. They appear red without blisters and pain typically lasts around three days. īurns that affect only the superficial skin layers are known as superficial or first-degree burns. Burns can also occur as a result of self-harm or violence between people (assault). Alcoholism and smoking are other risk factors. In the workplace, risks are associated with fire and chemical and electric burns. In the home, risks are associated with domestic kitchens, including stoves, flames, and hot liquids. Burns occur mainly in the home or the workplace. Most burns are due to heat from hot liquids (called scalding), solids, or fire. ![]() Pain medication, intravenous fluids, tetanus toxoid Ī burn is an injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or ultraviolet radiation (like sunburn). Open cooking fires, unsafe cook stoves, smoking, alcoholism, dangerous work environment Heat, cold, electricity, chemicals, friction, radiation Third degree: Area stiff and not painful įirst degree, Second degree, Third degree, Fourth degree Dermatology Critical care medicine, plastic surgery ![]() ![]() ![]() While the EpiC-low cluster was hypermethylated, immune-inflamed, enriched in MI cases, and harbored a high rate of somatic mutations of SWI/SNF genes, the EpiC-high cluster was hypomethylated, immune-desert, enriched for NMI cases, and harbored a high rate of FGFR3 mutations. In addition, we identified two methylome clusters, EpiC-low and EpiC-high, associated with distinct clinicopathological and genetic tumor features, as well as patient survival. We identified different key findings, including the discovery of novel mutations affecting the zinc-finger RNA-binding protein ZFP36L1 in 20% of cases, a rate by far the highest among cancer subtypes profiled to date. To fill this knowledge gap, we decided to investigate the putative contribution of both genetic and epigenetic alterations in dictating muscle invasiveness, a key predictor of poor outcome in UTUC patients. In fact, the recent remarkable study exploring genome-wide alterations of NMI bladder carcinomas did not include DNA methylation profiling. However, to our knowledge, epigenetic alterations in UTUC, in particular, DNA methylation, and their crosstalk with genetic and transcriptomic clinicopathological tumor features are unknown.Īlthough the epigenetic alterations of MI bladder carcinomas have been extensively studied by TCGA and other groups, comparative analysis of epigenetic alterations in MI relative to NMI bladder carcinomas has been limited, using often selected cancer-related genes or supervised analysis. At the transcriptomic level, UTUCs were mostly found to be luminal papillary and displayed T cell-depleted immune contexture, possibly related to the FGFR3 overexpression. Recent studies using whole-exome sequencing and/or targeted sequencing of UTUC samples identified recurrent mutations of genes known to be altered in bladder carcinomas, although with different frequencies (e.g., HRAS). While genome-wide genetic alterations of muscle-invasive bladder carcinomas have been extensively studied by The Cancer Genome Atlas (TCGA) project and others, genetic alterations occurring in UTUC are limited. Such differences might dictate whether patients with UTUC display a higher incidence of invasive disease at diagnosis as compared to patients with bladder carcinomas. Upper tract urothelial carcinomas represent 5–10% among all urothelial carcinomas, and they can arise within the ureter or the renal pelvis, which are derived from different embryonic tissues as compared to the bladder urothelium. NMI tumors are costly to treat as they often recur, and 10–15% of those patients progress to an MI state. NMI represents 75% of tumors, while MI represents the latter 25%. Urothelial carcinoma is considered the fifth most common cancer in Western countries, and it is divided at the pathological level into two groups: non-muscle-invasive (NMI) and muscle-invasive (MI) tumors, according to the level of invasion of the detrusor muscle. Our study delineates for the first time the key role for convergence between genetic and epigenetic alterations in shaping clinicopathological and immune upper tract urothelial carcinoma features. While the former is hypomethylated, immune-depleted, and enriched for FGFR3-mutated, the latter is hypermethylated, immune-infiltrated, and tightly associated with somatic mutations of SWI/SNF genes. ![]() Unsupervised DNA methylation subtype classification identifies two epi-clusters associated with distinct muscle-invasive status and patient outcome, namely, EpiC-low and EpiC-high. ![]() Overall, mutations of ZFP36 family genes ( ZFP36, ZFP36L1, and ZFP36L2) are identified in 26.7% of cases, which display a high mutational load. ![]() In addition to mutations of FGFR3 and KDM6A, we identify ZFP36L1 as a novel, significantly mutated tumor suppressor gene. We perform an integrative genome- and methylome-wide profiling of diverse non-muscle-invasive and muscle-invasive upper tract urothelial carcinomas. Crosstalk between genetic, epigenetic, and immune alterations in upper tract urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome are poorly understood. ![]() ![]() ![]() If you select to use the Magic Keyboard, you are also adding another USB-C port to the iPad Pro. Apple changed back to the reversed “T” design with the 16-inch MacBook Pro, and they also changed it for the Magic Keyboard for iPad Pro. In the Smart Keyboard Folio, Apple uses a smaller design for the arrow keys however, they are somewhat difficult to spot. Overall Overall, the Magic Keyboard is far more excellent and more robust.Ī minor but crucial aspect is the Arrow keys. However, it can be manually adjusted using options. ![]() ![]() It automatically adjusts based on the lighting of the room. The fabric keys are characterized by a “click” to them, but they’re very soft and can be “stuck” even when they aren’t being used. It’s not as waterproof as the Smart Keyboard Folio, but it’s much more responsive to type. The switch mechanism that uses a scissor for the keyboard is a significant improvement. It does consume some battery life, but only a significant amount. It’s also equipped with its Smart Connector but has a full mechanical keyboard that uses a scissor-switch mechanism and a glass trackpad. The Apple Magic Keyboard has much more than it has to offer. It is connected via its Smart Connector and has minimal impact on battery longevity. There are two angles of view available on the Smart Keyboard Folio, a more vertical angle for watching media and a more inclined angle to work from. This means there is no way for liquids to enter the keyboard the same is valid for dust and other particles. Apple produces these keyboards with a woven fabric made stiff around the keycaps. This Smart Keyboard Folio also has the advantage of being nearly 100% water-resistant. Innovative Keyboard Folio is far heavier than its counterpart, the Magic Keyboard, lending itself more flexibility for those who want to lower their weight as much as possible. In comparison to the Magic Keyboard, both are superior. However, this Smart Keyboard Folio has its advantages. The new design could have gone better, and users have looked at alternatives over the last year and a half. It was first introduced with the 2015 iPad Pro before being redesigned into a Smart Keyboard Folio in 2018 with the new iPad Pros. The Apple Smart Keyboard has been around for a while since. Both keyboards are compatible with the 12. On the other hand, the Smart Keyboard is a more compact keyboard that connects to your iPad Pro using the Smart Connector. ![]() ![]() ![]() ![]() Giannis Antetokounmpo, who is second to Curry with 177 fourth-quarter points, has played 24 more fourth-quarter minutes. I'll repeat: Curry has scored more fourth-quarter points than anyone else, despite player fewer fourth-quarter minutes than 92 other players. Fourth-quarter scoringĬurry leads the league with 179 total fourth-quarter points. But for a quick glance at the gap between Curry and and everyone else, have a look at the three numbers below. That doesn't mean Curry is going to win MVP the Warriors probably need to rise in the standings for that to become a reality, particularly with the way Jayson Tatum and the Celtics are rolling. It would be hard to argue there has been a better player in the league so far. You can also find us on Twitter and Facebook.Stephen Curry is having yet another MVP-level season, and even that undersells how dominant he's been. Want more NBA content? Be sure to give us a follow on Google News and Newsbreak to keep up with the latest around the league. A one-man show isn’t going to get Golden State to the promised land they have reached in four out of the last eight years. Kerr is finding places to rest Curry, but if the Warriors want to contend and compete at the level they know they are capable of, his teammates need to start producing at a higher level. However, if Curry wasn’t playing at this level, it would be difficult to pick out any games that they would have won decisively. Given the expectations of the franchise, it is hard to imagine things being worse than they are right now. Leading Warriors in PPG, RPG, APG and 3P%. The points, rebounds, assists and 3-point shooting percentage are all leading the Warriors. His efficiency has been through the roof as he is on pace to join the 50/40/90 club for the second time in his career as he is shooting 52.4 percent from the field, 44.4 percent from the 3-point line and 90.3 percent from the foul line. Curry is averaging 31.6 points, which is second in the NBA, with 7.2 assists, 6.6 rebounds and 1.1 steals per game. As pointed out by StatMuse, it is truly jaw-dropping the production that Curry is providing the team. He has picked up all of the slack as he is having an incredible season. The two-time MVP is playing at that level once again as he has been by far the team’s best player, carrying them through the first 19 games of the season. Stephen Curry has not experienced any struggles this season that Thompson has gone through. He is also a scorching 17-of-27 from 3-point range as the Warriors look to get out of their early-season funk. Thompson has looked like his vintage self in those victories, shooting a combined 27-of-49 from the field, the first three games this season that he made at least half of his shots in a game. LATEST NBA NEWS & STATS: Stephen Curry & Golden State Warriors Updates Golden State has won three out of their last four games, which is also coinciding with Klay Thompson breaking out of his season-long shooting slump. Kerr is relying more heavily on the veterans and it has worked. However, the Warriors are beginning to show some signs of life. The young players haven’t stepped up yet as the organization had hoped and Jordan Poole has taken a huge step back across the board. in free agency as they signed with the Portland Trail Blazers and Toronto Raptors, respectively. That is what happens when you lose key contributors such as Gary Payton II and Otto Porter Jr. Steve Kerr has struggled to get production from the second unit as the Warriors’ bench has been a mess thus far. There have been a few issues contributing to the team’s struggles in the early going. They have yet to find their form as the Warriors are 9-10, but they have started to find their footing in recent games. The 2022-23 NBA season has been a struggle thus far for the reigning NBA Champion Golden State Warriors. ![]() ![]() Once the version is determined, Renovate will look for newer versions from the gradle-version datasource. Renovate extracts the Gradle Wrapper version used from the distributionUrl inside the gradle-wrapper.properties. This includes the source declaration inside the gradle/wrapper/gradle-wrapper.properties as well as accompanied files such as gradlew, gradlew.bat, and gradle/wrapper/gradle-wrapper.jar. Renovate can update the Gradle Wrapper of a project. versions.toml (unless overridden via fileMatch configuration) Catalogs outside the gradle folder whose names do not end in.Catalogs with custom names that do not end in.Catalog versions using more than one of require, strictly, prefer in a single declaration.Catalog versions using reject, and rejectAll constraints.Android projects that require extra configuration to run (e.g.versions.props and versions.lock from the gradle-consistent-versions plugin.*.versions.toml files in any directory or *.toml files inside the gradleĭirectory ( Gradle Version Catalogs docs).Gradle lockfiles stored in *.lockfile files.Dependencies with version definitions in gradle.properties files.Renovate detects versions that are specified in a string 'group:artifact:version' and those specified in a map (group:groupName, name:ArtifactName, version:Version). ![]() ![]() Should you Pin your Javascript Dependencies? Support for mirrors and custom distributionsĬustom registry support, and authentication ![]() ![]() Some dogs are light brindle in color - mostly red with darker stripes. It can come in different shades and tones, and the pattern shapes vary. Not all brindle patterning is exactly the same. And not all brindle patterns appear in the same way in different dog breeds. ![]() To make matters even more complicated, not all dogs have a striped brindle coat. Sometimes called a trindle or tricolored coats. Plus, we know that all brindle dogs can still have white markings on their coat. Researchers have discovered which gene determines color intensity. And it’s still unclear what controls the various aspects of brindle, such as stripe width. We don’t yet know how to genetically test for the brindle coloring. So, it can be hard to predict what dogs with brindle coats will look like until they grow into their fur. Genes can act differently in different dog breeds. A particular combination of Agouti genes can even give rise to tricolor dogs! And different Agouti combinations determine how the brindle shows up in dogs. It switches on and off the red and black pigments in dogs. The Agouti gene is one of the most important genes involved in coloration. They also switch other pattern and color genes on and off too! So to be brindle requires a brindle gene, and a specific type of Agouti gene.īut, even with this combination present, the brindle will be switched off if another gene known as ‘dominant black’ is present! The Agouti Gene Dog coat color genes don’t just switch specific colors or patterns on and off individually. ![]() ![]() ![]() Medium heat is another great option for those playing it safe, but be warned, if you don’t have an adequate tolerance to spice, this is where you’ll start to feel the burn. You can taste some of the heat in the seasoning here, it’s a bit sweet and slightly smokey, with a heat that builds on the tongue as you make your way through the tender. This is where you go if you want to play it safe. The sauce brings a bit more heat to the table and makes the experience much more savory, but even if you like spice but you want to play it safe, this is playing it too safe. I can certainly see the paprika and cayenne pepper, but this comes across as more sweet than spicy. Lite mild is an understatement, I wasn’t getting any spicy notes here. The chicken tender is gigantic! The chicken is well fried and tender, the exterior isn’t Popeyes-style crunchy, but it’s flavorful, with a heavy dose of black pepper. Odd as it is, I appreciate it for giving me a clear picture of the baseline Dave’s is working with. I’m not entirely sure who this is for but it just seems odd to roll up to Dave’s Hot Chicken and get the chicken with no spice. ![]() But it was quite the experience and now I feel intimately knowledgeable of every different level and what each brings to the table.Įach order of tenders is served atop a single slice of white bread with a side of pickles and a way-too-small dip cup of sauce (a mix of mayo, chipotle pepper, a hint of sugar, honey, and maybe mustard). Plus there are 7 different spice levels (no spice, lite mild, mild, medium, hot, extra hot, and reaper) - and we tried them all!ĭid I need to eat 7 different spice levels to get an idea of whether or not Dave’s is any good? Truthfully, no. But they also serve up milkshakes and a handful of sides. Okay, granted, Dave’s Hot Chicken has one specialty - giant, baby-arm-sized chicken tenders and chicken sliders (which are made using the same tenders). There was only one way to find out: we had to eat the entire menu. So does Dave’s live up to the hype? Is the food worth all this buzz? That’s bananas growth - an average of one new location opening up every five days. ![]() Today, Dave’s Hot Chicken currently has 700 franchise locations across the US, Middle East, and Canada, and 70 locations set to open up this year. The concept was dreamed up by Dave Kopushyan (the titular “Dave,” who trained in Thomas Keller’s French Laundry), Arman Oganesyan, and brothers Tommy and Gary Rubenyan, who took $900 dollars and flipped the money into a viral chicken sensation serving some of the most Instagrammable food ever found in a parking lot. In just six short years, the hot chicken joint Dave’s Hot Chicken went from being a four-man East LA parking lot pop-up to one of the fastest-growing restaurants in America, attracting early investment interest from Drake and later from Maria Shriver, Samuel L. ![]() ![]() ![]() Alternative subway tile patterns include a one-third offset and a one-fourth offset. ![]() However, modern interpretations of subway tile often take liberties with this pattern, or even abandon it altogether. What is the subway tile pattern? Subway tiles are traditionally laid in a 50% offset, meaning that the middle of the tile aligns with the edges of the two tiles above or beneath it. Let’s get more specific: Here are some frequently asked questions about subway tile. Using plain white rectangle tiles and a simple tile layout, subway tile has managed to create a design that’s equally impactful and easy to achieve. We have to chalk it up to the inherent timelessness of the subway tile design. Over 100 years old, subway tile remains a favorite for home and business owners alike. We often get asked: Is subway tile a fad? While the incredible popularity of this tile design may make you wonder if it’s just another short-lived trend, its longevity is a major clue that this isn’t the case. Today, subway tile’s popularity continues to grow. Its sanitary appearance and health benefits meant that it was soon being used anywhere hygiene was a concern, including kitchens and bathrooms. Is Subway Tile Still Popular?Īfter its inception in 1904, subway tile went on to appear in other transportation hubs around the world. Additionally, the white and glossy design of the first subway tiles formed a highly reflective surface that helped create a safe, sanitary feeling for passengers who may have had concerns about travelling underground. Victorians prioritized hygiene, so easy-to-clean, stain-resistant, and bacteria-resistant ceramic tile was a natural choice. When designers were tasked with designing a surface that was both low-maintenance and bright for the first subway station in 1904, subway tile was born. You might be wondering, why are subway tiles called subway tiles? The answer: They were first used in New York subway stations. Why Do They Call It Subway Tile? Photo via | Photo by David Sagarin, Library of Congress, Prints and Photographs Division, Historic American Engineering Record, August 1978 Made of ceramic tile, subway tile is known for both its durability and its timeless style. The term “ subway tile” typically refers to rectangular tiles (usually 3 x 6 inches) laid horizontally with a 50% offset. We’re here to help! We’ve included a little historical perspective, the general characteristics of traditional subway tile, creative subway tile installation patterns and adaptations, and some ideas on how to use subway tile in your home. Subway tile: you’ve heard of it and admired it, but do you really know what makes subway tile subway tile? Eastland-Fairfield Career and Technical Schools.As an added bonus the backing paper is degradable.Facebook page opens in new window Twitter page opens in new window Instagram page opens in new window Pinterest page opens in new window They’ll stay up until the day you decide you want to jump on the next trend. Wait, PET what? - It just means that these tiles won’t turn yellow from the sun or be scratched from cleaning. The tiles are hard wearing and scratch resistant and if we're getting technical they are made with a PET substrate.Why so thick? Because they hide imperfections better! The Subway tiles are 32cm (W) x 26.9cm (H) and a whopping 2mm thick! That is thicker than any other low budget peel and stick tile on the market.The tiles can be installed by you or by any friend or family member you wish to bribe. No extra glue is required and definitely no grout or tradesmen. That’s right peel off the backing paper and stick them to your wall like a jigsaw puzzle. For anyone wondering, this means they have a sticky back and can just be stuck to a wall. One of the positives to our wall tiles is that they are easy to install as they are self-adhesive.Do us both a favour and check out the guide! If you skip this step your project may not look top notch and you certainly won’t give us a 5 star review that we so desperately want. When it comes to installation - don’t be a ‘know it all’.Of course you still need to measure the surface you intend to cover in mm but this should really help and make the buying process easy! Plus we have some super saver bundles so make sure you check these out! Don’t stress it, our handy calculator above is designed to quickly find out approximately how many tiles your project requires. You may be wondering how you calculate how many packs of tiles you need. ![]() On average most jobs require a couple of packs of tiles so bare in mind that our packs contain 4 sheets of tiles. |
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